en Clinical Original Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> One of the treatment methods used for influenza is the administration of antiviral medications, including oseltamivir. This study aimed to investigate the impact of the timing of oseltamivir treatment on clinical indicators and complications in hospitalized children with influenza.<br> <b>Methods:</b> This cross-sectional study was conducted on all children diagnosed with influenza who visited Taleghani Hospital in 2024. Demographic information, clinical indicators, including oxygen saturation, fever, general condition, oral intolerance, and disease outcomes such as length of hospital stay and complications were recorded using a researcher-designed checklist. The collected data were entered into SPSS software version 23.<br> <b>Results:</b> In this study, 134 children with influenza, with a mean age of 63 &plusmn; 42 months, were examined. Among them, there were 69 males and 65 females. Fever, cough, and loss of appetite were the most prevalent symptoms, occurring in 83%, 65%, and 62% of the cases, respectively. Sore throat and eye pain were the least common symptoms, reported at 9% and 10%. A total of 87 participants received oseltamivir. The overall recovery rate was 74% in the entire study population, as well as among those who received oseltamivir, and only one death was observed.<br> <b>Conclusion</b>: Based on the results, early treatment with oseltamivir has been effective in reducing clinical symptoms of influenza in affected children. Therefore, it is advisable to initiate treatment with this medication promptly upon the admission of sick children to the hospital.</span></span><br> &nbsp;</div> Influenza, Human, Antiviral Medications, Oseltamivir 5 9 http://jhd.goums.ac.ir/browse.php?a_code=A-10-41-3&slc_lang=en&sid=1 Mousa Ghelichi-Ghojogh m.ghelichi97@gmail.com 1003194753284600513 1003194753284600513 No Children’s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran ; Department of Biostatistics and Epidemiology, School of Health, Golestan University of Medical Sciences, Gorgan, Iran Abdolmatalleb Koohsarian drkoohsarian@gmail.com 1003194753284600514 1003194753284600514 No Children’s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran Jabbar Parhiz drparhiz2014@gmail.com 1003194753284600515 1003194753284600515 Yes Children’s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran